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⥕ Download Format Kindle [  Ꮍ The Cancer Chronicles: Unlocking Medicine's Deepest Mystery ] For Free ⦛ Author George Johnson 䍲 ⥕ Download Format Kindle [ Ꮍ The Cancer Chronicles: Unlocking Medicine's Deepest Mystery ] For Free ⦛ Author George Johnson 䍲 Chapter 1Jurassic CancerAs I crossed a dry, lonesome stretch of the Dinosaur Diamond Prehistoric Highway, I tried to picture what western Coloradoa wilderness of sage covered mesas and rocky canyonslooked like 150 million years ago, in Late Jurassic time North America was breaking away from Europe and Asiaall three had formed a primordial supercontinent called Laurasia The huge land mass, flatter than it is today, was drifting northward a few centimeters per year and was passing like a ship through the waters of what geographers would come to call the Tropic of Cancer Mile high Denver was near sea level and lay about as far south as where the Bahamas are today Though the climate was fairly dry, webs of rivulets connecting shallow lakes and swamps covered part of the land, and vegetation abounded There were no grasses or flowersthey had yet to evolvejust a weird mix of conifers commingling with ginkgos, tree ferns, cycads, and horsetails Giant termite nests soared as much as thirty feet high Splashing and stomping through this Seuss like world were Stegosaurus, Allosaurus, Brachiosaurus, Barosaurus, Seismosaurustheir bones buried far below me as I made my way from Grand Junction to a town called Dinosaur.Occasionally one can glimpse outcroppings of the Jurassic past, exposed by erosion, seismological uplift, or a highway department road cutcolorful bands of sediment that form a paleontological treasure house called the Morrison Formation I knew what to look for from photographs crumbling layers of reddish, grayish, purplish, sometimes greenish sedimentgeological debris piled up over some 7 million years.Just south of the town of Fruita on the Colorado River, I hiked to the top of Dinosaur Hill, stopping for a moment to pick up a pinch of purplish Morrison mudstone that had fallen near the trail As I rolled it in my fingers it crumbled like dry cookie dough On the far side of the hill, I came to a shaft where in 1901 a paleontologist named Elmer Riggs extracted 6 tons of bones that had belonged to an Apatosaurus the proper name for what most of us call a Brontosaurus Alive and fully hydrated, the 70 foot long reptile would have weighed 30 tons Riggs encased the bones in plaster of paris for protection, ferried them across the Colorado on a flat bottom boat, and then shipped them by train to the Field Museum in Chicago, where they were reassembled and put on display.After making my way north to Dinosaur population 339 , where Brontosaurus Boulevard intersects Stegosaurus Freeway, I stood at an overlook and watched Morrison stripes in a canyon reddening with the setting sun But it was a little farther west, along the Green River in the western reaches of Dinosaur National Monument, that I saw the most beautiful example a cliffside of greenish grays slumping into purples slumping into browns It indeed resembled, as the woman at the park headquarters had told me, melted Neapolitan ice cream.It was somewhere in these parts that a dinosaur bone was discovered that displays what may be the oldest known case of cancer After the dinosaur died, whether from the tumor or something else, its organs were eaten by predators or rapidly decomposed But the skeletonat least a piece of itgradually became buried by windblown dirt and sand Later on, an expanding lake or a meandering stream flowed over the debris, and the stage was set for fossilization Molecule by molecule minerals in the bones were slowly replaced by minerals dissolved from the water Tiny cavities were filled and petrified Several epochs later dinosaurs were long extinct, their world overlaid by lakes and deserts and oceans, but this fossilized bone, encased in sedimentary rock, was preserved and carried through time.That hardly ever happened Most bones disintegrated before they could become fossilized And of the fraction that survived long enough to petrify, all but a few remain buried The specimen, now labeled CM 72656 and housed at the Carnegie Museum of Natural History in Pittsburgh, was a survivor Unearthed by a rushing river or exposed by tectonic forcessomehow it was delivered to the surface of our world where, 150 million years after the animal died, it was discovered by some forgotten rockhound A cross section was cut with a rock saw, polished, and after passing through who knows how many human hands, the fossil found its way to a Colorado rock shop where it caught the eye of a doctor who thought he knew a case of bone cancer when he saw one.His name was Raymond G Bunge, a professor of urology at the University of Iowa College of Medicine In the early 1990s, he telephoned the schools geology department to ask if someone would come evaluate a few prize specimens in his collection The call made its way through the switchboard to Brian Witzke, who on a cold autumn day bicycled to the doctors house and was presented with an attractive chunk, 5 inches thick, of mineralized dinosaur bone Viewed head on, the fossil measured 6.5 by 9.5 inches Lodged inside its core was an intrusion, now crystallized, that had grown so large it had encroached into the outer bone Bunge suspected osteosarcomahe had seen the damage the cancer can do to human skeletons, particularly those of children Oval in shape and the size of a slightly squashed softball, the tumor had been converted over the millennia into agate.The fragment was too small for Witzke to identify the bone type or the species of dinosaur, but he was able to provide a geological diagnosis The reddish brown color and the agatized center were clues that it came from the Morrison Formation Bunge remembered buying the souvenir somewhere in western Coloradoburnished pieces of petrified dinosaur bone were a favorite among collectorsbut he couldnt remember the precise location He gave the rock to the geologist, asking that he seek an expert opinion.Other projects intervened, and so the fossil sat almost forgotten atop a filing cabinet in Witzkes office, until the day he sent it to Bruce Rothschild, a rheumatologist at the Arthritis Center of Northeast Ohio who had expanded his practice to include dinosaur bone disease He had never seen a clearer or ancient example of prehistoric cancer His next step was to determine just what kind of cancer it was.The tumor, it turned out, didnt exhibit the ill defined margins or the layered, onion skin look of an osteosarcoma, the cancer Bunge had suspected, or of another malignancy called Ewings sarcoma Rothschild also felt confident in ruling out myeloma, a cancer of plasma cells that leaves bone with a punched out appearance The fact that the tumor, gnawing its way outward, had left intact a thin shell of bone was reason to exclude the invasive multiple myeloma Every skeletal disease leaves a distinct engraving and, one by one, Rothschild eliminated the possibilities the superficial solitary and coalescing pits of leukaemia, the expansile, soap bubble appearance of aneurysmal bone cysts, the epiphyseal popcorn calcifications characteristic of chrondroblastomas, the ground glass appearance of fibrous dysplasia.For an outsider reading Rothschilds observations, the medical jargon might be somewhere between translucent and opaque, words that gain a grim familiarity only as one strives to understand the sudden disruption of cancer What is clear from the beginning is the confidence with which a specialist in the obscure discipline of dinosaur pathology can provide a likely diagnosis for a 150 million year old tumor Rothschild went on to rule out the sclerotic rimmed lesions of gout, the zones of resorption characteristic of tuberculosis, and the sclerotic features of gummatous lesions of treponemal disease Unicameral bone cysts, enchondromas, osteoblastomas, chondromyoxoid fibromas, osteoid osteoma, eosinophilic granulomawho would have known that so much can go wrong inside what appears to be solid bone None of these seemed like candidates To Rothschilds eye the lesion had the markings of a metastatic cancer, the deadliest kinda cancer that had originated from cells elsewhere in the dinosaurs body and migrated to establish a colony in the skeleton.There had been scattered references in the journals to other dinosaur tumorsosteomas clumps of overeager bone cells outgrowing their rightful bounds and hemangiomas abnormal effusions of blood vessels that can form within the spongy tissue inside bone Like cancer, these benign tumors are a kind of neoplasm from the Greek for new growth cells that have learned to elude the bodys checks and balances and exert a will of their own The cells in a benign tumor are multiplying rather slowly and have not acquired the ability to invade surrounding tissue or to metastasize They are not necessarily harmless Occasionally a benign tumor can press dangerously against an organ or blood vessel or secrete destructive hormones And some can become cancerous These were rare enough But sightings of malignant dinosaur tumors were especially scarce A cauliflower like growth in the forelimb of an Allosaurus was thought for a while to be a chondrosarcoma But on close examination Rothschild decided that it was just a healed fracture that had become infected Bunges fossil was the real thing In a terse, five hundred word paper written with Witzke and another colleague and published in The Lancet in 1999, he came to a bold conclusion This observation extends recognition of metastatic cancer origins to at least the mid Mesozoic the Age of the Dinosaurs , and is the oldest known example from the fossil record.Id first heard of Raymond Bunges fossil earlier that summer when I began working my way through the literature on the science of cancer There is something sickly fascinating about the way a single cell can break from the pack and start multiplying, creating something alien inside youlike a new organ suddenly sprouting in the wrong place or, even gruesome, a vicious, misshapen embryo Teratomas, rare tumors that arise from misguided germ cells the ones that give rise to eggs and sperm , can contain the rudiments of hair, muscle, skin, teeth, and bone Their name is from the Greek word teras, for monster A young Japanese woman had an ovarian cyst with head, torso, limbs, organs, and a cyclopean eye But these cases are very rare Tumors almost always evolve according to their own impromptu plan The most dangerous ones become mobile Once they have established themselves in the immediate vicinityyour stomach, your colon, your uterusthey move on, metastasize, to new ground A cancer that began in the prostate gland can end up in the lungs or the spinal column There was no reason to believe that cancer hadnt occurred in dinosaurs But considering the tiny fraction of paleontological remains that humans have had the opportunity to examine, coming across an actual example seemed almost miraculous.Consider the size of the field From Dinosaur National Monument in Utah and Colorado, the Morrison Formation reaches north into Wyoming, Idaho, Montana, the Dakotas, and southern Canada It spreads east to Nebraska and Kansas, and south to the panhandles of Texas and Oklahoma, and into New Mexico and Arizona It covers approximately half a million square miles Erosion and excavation, natural or man made, have only nicked the edges, barely sampling the 7 million year accumulation of dinosaur bones, and only those that happened to become fossilized If it hadnt been for Raymond Bunges sharp eye, the earliest solid evidence of prehistoric cancer would have been missed How many other cases were crushed inside those lightless layers And among the bones that have been retrieved, how many malignancies had been overlooked Paleontologists were hardly ever looking for cancerfew would recognize it if they saw itand the only tumors they had a chance of finding would be those that had tunneled their way outward to a bones surface or had been revealed by a random fracture or the blind cut of a lapidary saw.One of the most elusive questions about cancer is how much is timeless and inevitablearising spontaneously inside the bodyand how much has been brought on by pollution, industrial chemicals, and other devices of man Getting a rough sense of the frequency of cancer in earlier epochs might provide important clues, but only with a larger sample of data His interest piqued by Bunges fossilized tumor, Rothschild began looking for .With a portable fluoroscope, he began x raying his way through the museums of North America In people, cancers that metastasize to the skeleton most commonly lodge in the spine, so Rothschild concentrated on vertebrae By the time he was done he had examined 10,312 vertebrae from about seven hundred dinosaurs collected by the American Museum of Natural History in New York, the Carnegie Museum in Pittsburgh, the Field Museum in Chicago, and other institutions throughout the United States and Canadaevery specimen north of the Mexican border that he could get his hands on He inspected loose vertebrae and, using ladders and a cherry picker, the soaring spines of whole skeletons There is a picture of him wearing a dinosaur T shirt and leaning backward inside the rib cage of a Tyrannosaurus rex Bones that appeared abnormal under x rays were scrutinized closely with a CT scan.In the end, his diligence paid off He found another bone metastasis, and this time it was possible to identify the victim an Edmontosaurus, a duck billed titan the family name is Hadrosauridae that lived toward the end of the Cretaceous, right after the Jurassic, when dinosaurs began to go extinct Other Hadrosauridae also had bone tumors, all of them benign an osteoblastoma, a desmoplastic fibroma, and twenty six hemangiomas, but there were none among the other beasts That perhaps was the biggest surprise Although Hadrosauridae vertebrae made up less than one third of the bone pileabout 2,800 specimens from fewer than one hundred dinosaursthey were the source of all the tumors The approximately 7,400 vertebrae that were not hadrosaursApatosaurus, Barosaurus, Allosaurus, and so forthexhibited no neoplasms, either malignant or benign.It was the kind of anomaly epidemiologists of human cancer confront all the time Why do some people get cancer than others Some evolutionary twist may have left Hadrosaurus with a genetic predisposition for tumors Or the reason might have been metabolic These dinosaurs, Rothschild speculated, may have been warm blooded than other ones Warm blooded metabolisms run fasterit takes energy to maintain body heatand that might accelerate the accumulation of the cellular damage that leads to malignancy.Maybe the difference was not endemic but environmentalsomething about what Hadrosaurus ate Plants in an ecosystem engage in endless chemical warfare, synthesizing herbicides and insecticides to fight off pests Some of these chemicals are mutagens they can change DNA Modern descendants of the fernlike cycads that grew in Mesozoic times produce poisons that can induce liver and kidney tumors in laboratory rats But why would Hadrosaurus eat cycads than, say, Apatosaurus Another possible source of carcinogensneedles from conifer treeshad been discovered in the stomachs of a couple of Edmontosaurus mummies, whose remains had been buried under the right environmental conditions to fossilize instead of rot But that wasnt much evidence to go on.Gripping, illuminating, affecting Not since Susan Sontag has anyone put cancer so firmly and eloquently in its place Johnsons deceptively casual narrative route is cannily chosen He wanders everywhere, an intelligent, skeptical, interested and saddened observer The New York Times A masterpiece of clarity New York Journal of Books Graceful Among a small cluster of very good recent books on cancer Johnsons stands out as especially illuminating, forceful and, in its own quiet way, profound Not only is Johnson an excellent explainer, but unlike some of our most esteemed explainers, he can really write He knows that economy, poetry and rhythm are to be valued as well as clarity The scientific story Johnson tells, in so few pages, is large and rich The personal story is a sad and anguished one, partly in ways you wouldnt expect A forthright and human and exhilaratingly gloomy book The New York Times Book Review Incisive An astute, vivid biography of perhaps the oldest, most complex disease on Earth, and a poignant account of a contemporary couples struggle against it NPRThe ideal primer for those who want to know the real story of cancer, rather than the version that is usually presented in the media The EconomistJohnsons fine work is an important one The Atlantic A provocative and also a personal exploration of the myths and misunderstandings that surround this most formidable enemy to our health and well being Mother Jones A fascinating compilation of selected discoveries in cancer research The author has deftly organized and presented vast amounts of scientific information so that they support the personal chronicle every example seems to fit In addition, the book is artfully written Throughout it, Johnsons use of metaphor provides novel descriptions that are interesting to any reader, whether seasoned in the science of cancer or a novice The book succeeds because Johnsons writing conveys his passion about the science Science George Johnson, like a science writing alchemist, transforms his fearfueled by his wife Nancys metastatic cancer diagnosisinto gold, in the form of a well written and thoroughly researched exploration of the current state of cancer science Johnson journeys through labs bent on cracking cancers code, ferreting out its causes, its molecular eccentricities, and its treatment His wifes struggle with the disease serves as a constant touchstone without subsuming his sober treatment of evidence, data, and reason The Scientist An enormously well researched and somewhat iconoclastic look at cancer and cancer research It provides a rare and highly readable view of what we knowand what we dont knowabout the disease.Bert Vogelstein, Director, Ludwig Center at the Sydney Kimmel Johns Hopkins Cancer Center A highly captivating book that meticulously explains the current scientific understanding of cancer George Johnson has captured the curiosity and empathy that drives scientists to tackle this calamitous disease The Times Literary Supplement Johnson writes with imaginative flair about the whole range of the cancer experience Bloomberg Businessweek It is very rare to find a writer who can weave a compelling narrative that combines the intrinsically fascinating nature of cancer with its peculiar horror For those who want to gain some serious insights into the subject, this book is a great place to start.Paul Davies, Principal Investigator, Center for Convergence of Physical Science and Cancer Biology This compact, elegant book is really three books a memoir of a year in Cancerland, a shrewd investigation into whats known and not known about this still mysterious condition, and a gripping account of coming to terms with living in a universe that includes a deadly disease with no predictable cause Everyone who is concerned about cancerthat is, every thinking adultshould read The Cancer Chronicles.Charles C Mann, author 1491 The Cancer Chronicles is a rich and sweeping exploration of the history, prehistory, and future of cancer, all anchored in harrowing personal experience Completely accessible to the lay reader, this is a book for anyone whose life has been touched by cancer, which is just about everyone.Barbara Ehrenreich, author, Nickel and Dimed Richly informative, unerringly balanced and undeniably compelling Shelf Awareness This elegant and insightful chronicle is at once intensely personal and meticulously studious This is extraordinary scholarship delivered with an intimate poignancy Publishers Weekly A thorough and nuanced presentation of the state of cancer science, refreshing in its honest appraisal that the war is far from over Kirkus Reviews The Starfish Chronicles A Cancer Warrior s Memoir The Heather Davis Johnson, Jeremiah Davis, Jen Queen on FREE shipping qualifying offers Johnson was a year old wife and mother of two small girls when she diagnosed with Stage colon cancer She resolved during her five years treatment to write about experiences Colorectal Wikipedia Colorectal CRC , also known as bowel cancer, is the development from or rectum parts large intestine abnormal growth cells that have ability invade spread other body Signs symptoms may include blood in stool, change movements, weight loss, feeling tired all time Photographing His Own Treatment Hell I Wasn t Jul Mark Richards chronicled his battle visualizing agony he endured Official site Stephen Fry UK comedian, actor, writer, presenter Since January bought my first Apple Macintosh, through dark late mid company had but % personal computer market, developed thickest skins it comes haters Roger Zelazny Roger Joseph May June an American poet writer fantasy science fiction short stories novels, best for AmberHe won Nebula award three times out nominations Hugo Freddy Fender New museum San Benito chronicles Freddy Fender life Web Posted PM CST Elaine Ayala Express News Staff Writer SAN BENITO It by no means big city Breast But DoctorI hate pink Despite having metastatic, IV, breast Ann Silberman, writes humorous blog while detailing treatments such mastectomy, herceptin, reconstruction, surgeries First Comes Breast Cancer, Then Divorce Beth Oh Beth, this so honest raw real feel like giving you great hug applaud And m sorry go alone Log Cabin frameset lccml tomifobia John Mahoney Log publishes quality features, fiction, poetry, opinion, photography, art, recipes down home 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    • The Cancer Chronicles: Unlocking Medicine's Deepest Mystery
    • 1.1
    • 19
    • Format Kindle
    • 304 pages
    • 030774230X
    • George Johnson
    • Anglais
    • 06 July 2016

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