Ɯ Purpose of textOligonucleotide-Based Drugs and Therapeutics: Preclinical and Clinical Considerations for Development ყ PDF Author 13usednewfrom ᄙ

Ɯ Purpose of textOligonucleotide-Based Drugs and Therapeutics: Preclinical and Clinical Considerations for Development ყ PDF Author 13usednewfrom ᄙ Ɯ Purpose of textOligonucleotide-Based Drugs and Therapeutics: Preclinical and Clinical Considerations for Development ყ PDF Author 13usednewfrom ᄙ A comprehensive review of contemporary antisense oligonucleotides drugs and therapeutic principles, methods, applications, and researchOligonucleotide based drugs, in particular antisense oligonucleotides, are part of a growing number of pharmaceutical and biotech programs progressing to treat a wide range of indications including cancer, cardiovascular, neurodegenerative, neuromuscular, and respiratory diseases, as well as other severe and rare diseases Reviewing fundamentals and offering guidelines for drug discovery and development, this book is a practical guide covering all key aspects of this increasingly popular area of pharmacology and biotech and pharma research, from the basic science behind antisense oligonucleotides chemistry, toxicology, manufacturing, to safety assessments, the design of therapeutic protocols, to clinical experience.Antisense oligonucleotides are single strands of DNA or RNA that are complementary to a chosen sequence While the idea of antisense oligonucleotides to target single genes dates back to the 1970 s, most advances have taken place in recent years The increasing number of antisense oligonucleotide programs in clinical development is a testament to the progress and understanding of pharmacologic, pharmacokinetic, and toxicologic properties as well as improvement in the delivery of oligonucleotides This valuable book reviews the fundamentals of oligonucleotides, with a focus on antisense oligonucleotide drugs, and reports on the latest research underway worldwide. Helps readers understand antisense molecules and their targets, biochemistry, and toxicity mechanisms, roles in disease, and applications for safety and therapeutics Examines the principles, practices, and tools for scientists in both pre clinical and clinical settings and how to apply them to antisense oligonucleotides Provides guidelines for scientists in drug design and discovery to help improve efficiency, assessment, and the success of drug candidates Includes interdisciplinary perspectives, from academia, industry, regulatory and from the fields of pharmacology, toxicology, biology, and medicinal chemistry Oligonucleotide Based Drugs and Therapeutics belongs on the reference shelves of chemists, pharmaceutical scientists, chemical biologists, toxicologists and other scientists working in the pharmaceutical and biotechnology industries It will also be a valuable resource for regulatory specialists and safety assessment professionals and an important reference for academic researchers and post graduates interested in therapeutics, antisense therapy, and oligonucleotides. Oligonucleotide Analysis and Bioanalysis Intertek Oligonucleotide therapeutic analysis for identity, purity, quality, strength, structure characterisation, physicochemical properties bioanalysis supporting antisense other oligo product development Aptamer Wikipedia Aptamers from the Latin aptus fit, Greek meros part are oligonucleotide or peptide molecules that bind to a specific target molecule usually created by selecting them large random sequence pool, but natural aptamers also exist in riboswitchesAptamers can be used both basic research clinical purposes as macromolecular drugs Factor XI Antisense Prevention of Background Experimental data indicate reducing factor levels attenuates thrombosis without causing bleeding, role prevention postoperative venous Molecular Therapy Family Journals Cell Press Currently, there no issues progress The most recently published articles may viewed Current Issue In added soon they available so check back later Mongersen, an Oral SMAD 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    • Oligonucleotide-Based Drugs and Therapeutics: Preclinical and Clinical Considerations for Development
    • 1.2
    • 22
    • Kindle
    • 1118537335
    • 13usednewfrom
    • English
    • 05 January 2016

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