☏ Free eTextbook Download @The Gene: An Intimate History ☿ By Siddhartha Mukherjee ♭

☏ Free eTextbook Download @The Gene: An Intimate History ☿ By Siddhartha Mukherjee ♭ ☏ Free eTextbook Download @The Gene: An Intimate History ☿ By Siddhartha Mukherjee ♭ An Best Book of May 2016 In 2010, Siddhartha Mukherjee was awarded the Pulitzer Prize for his book The Emperor of All Maladies, a biography of cancer Here, he follows up with a biography of the geneand The Gene is just as informative, wise, and well written as that first book Mukherjee opens with a survey of how the gene first came to be conceptualized and understood, taking us through the thoughts of Aristotle, Darwin, Mendel, Thomas Morgan, and others he finishes the section with a look at the case of Carrie Buck to whom the book is dedicated , who eventually was sterilized in 1927 in a famous American eugenics case Carrie Bucks sterilization comes as a warning that informs the rest of the book This is what can happen when we start tinkering with this most personal science and misunderstand the ethical implications of those tinkerings Through the rest of The Gene, Mukherjee clearly and skillfully illustrates how the science has grown so much advanced and complicated since the 1920swe are developing the capacity to directly manipulate the human genomeand how the ethical questions have also grown much complicated We could ask for no wiser, fascinating and talented writer to guide us into the future of our human heredity than Siddhartha Mukherjee Chris SchluepThis is perhaps the greatest detective story ever tolda millennia long search, led by a thousand explorers, from Aristotle to Mendel to Francis Collins, for the question marks at the center of every living cell Like The Emperor of All Maladies, The Gene is prodigious, sweeping, and ultimately transcendent If youre interested in what it means to be human, today and in the tomorrows to come, you must read this book Anthony Doerr, author of All the Light We Cannot See The Gene is a magnificent synthesis of the science of life, and forces all to confront the essence of that science as well as the ethical and philosophical challenges to our conception of what constitutes being human Paul Berg, winner of the Nobel Prize in Chemistry Praise for The Emperor of All MaladiesWith this fat, enthralling, juicy, scholarly, wonderfully written history of cancer, Siddhartha Mukherjee vaults into that exalted company, inviting comparisons to the late physician and historian Lewis Thomas and the late palaeontologist and historian of science Stephen Jay Gould What a storyfull of quixotic characters, therapeutic triumphs and setbacks, and recent historical eventswith all the hubris and pathos of Greek tragedy Susan Okie, Washington Post Magisterial Siddhartha Mukherjees work is a small miracle of insight, scope, pace, structure and lucidity Reading The Emperor of All Maladies is a sharpening, clarifying and moving experience One of the best reading experiences of my life Karen Long, The Cleveland Plain Dealer Powerful and ambitious One of the most extraordinary stories in medicine The New York Times Book Review Its hard to think of many books for a general audience that have rendered any area of modern science and technology with such intelligence, accessibility, and compassion The Emperor of All Maladies is an extraordinary achievement The New Yorker Stirring A compulsively readable, surprisingly uplifting and vivid tale O, the Oprah Magazine Mukherjee brings an impressive balance of empathy and dispassion to this instantly essential piece of medical journalism Time A meticulously researched, panoramic history What makes Mukherjee s narrative so remarkable is that he imbues decades of painstaking laboratory investigation with the suspense of a mystery novel and urgency of a thriller The masterful analogies in this volume should earn Mukherjee a rightful place alongside Carl Sagan, Stephen Jay Gould, and Stephen Hawking in the pantheon of our epoch s great explicators Boston Globe Riveting and powerful Mukherjees extraordinary book might stimulate a wider discussion of how to wisely allocate our precious health care resources San Francisco Chronicle Now and then a writer comes along who helps us fathom both the intricacies of a scientific specialty and its human meaning Lewis Thomas, Sherwin Nuland, and Oliver Sacks come to mind Add to their company Siddhartha Mukherjee oncologist, researcher, and author of The Emperor of All Maladies Scribner , a sweeping, erudite, and challenging biography of cancer Elle magazine Rich and engrossing The Economist A brilliant, riveting history of the disease Entertainment Weekly Grade A Informative, elegant, comprehensive and lucid Pittsburgh Post Gazette Compelling Highly recommended Booklist, starred review Sobering, humbling, and extraordinarily rich reading from a wise and gifted writer who sees how far we have comebut how much farther far we have to go to understand our human nature and destiny Kirkus, starred review Mukherjee deftly relates the basic scientific facts about the way genes are believed to function, while making clear the aspects of genetics that remain unknown He offers insight into both the scientific process and the sociology of science By relating familial information, Mukherjee grounds the abstract in the personal to add power and poignancy to his excellent narrative Publishers Weekly, starred review A magisterial account of how human minds have laboriously, ingeniously picked apart what makes us tick The Gene will confirm Mukherjee as our eras preeminent popular historian of medicine The Gene boats an even ambitious sweep of human endeavor than its predecessor Mukherjee punctuates his encyclopedic investigations of collective and individual heritability, and our closing in on the genetic technologies that will transform how we will shape our own genome, with evocative personal anecdotes, deft literary allusions, wonderfully apt metaphors, and an irrepressible intellectual brio Ben Dickinson, Elle Magnificent The story of the gene has been told, piecemeal, in different ways, but never before with the scope and grandeur that Siddhartha Mukherjee brings to his new history he views his subject panoptically, from a great and clarifying height, yet also intimately James Gleick, New York Times Book Review Many of the same qualities that made The Emperor of All Maladies so pleasurable are in full bloom in The Gene The book is compassionate, tautly synthesized, packed with unfamiliar details about familiar people Jennifer Senior, The New York Times Mukherjees visceral and thought provoking descriptions clearly show what he is capable of, both as a writer and as a thinker Matthew Cobb, Nature His topic is compelling And it couldnt have come at a better time Courtney Humphries, Boston Globe Mukherjee nourishes his dry topics into engaging reading, expresses abstract intellectual ideas through emotional stories and swaddles his medical rigor with rhapsodic tenderness, surprising vulnerability, and occasional flashes of pure poetry With a marriage of architectural precision and luscious narrative, an eye for both the paradoxical detail and the unsettling irony, and a genius for locating the emotional truths buried in chemical abstractions, Mukherjee leaves you feeling as though you ve just aced a college course for which you d been afraid to register and enjoyed every minute of it Andrew Solomon, Washington Post The Gene is equally authoritative to Emperor , building on extensive research and erudition, and examining the Gordian knots of genes through the prism of his own familys struggle with a disease He renders complex science with a novelists skill for conjuring real lives, seismic events Hamilton Cain, Minneapolis Star Tribune A fascinating and often sobering history of how humans came to understand the roles of genes in making us who we areand what our manipulation of those genes might mean for our future The Gene captures the scientific methodquestioning, researching, hypothesizing, experimenting, analyzingin all its messy, fumbling glory, corkscrewing its way to deeper understanding and new questions Jim Higgins, Milwaukee Journal Sentinel This is an intimate history This is a meticulous history This is a provocative history Most of all, this is a readable history The Gene is a story that, once read, makes us far better educated to think about the profound questions that will confront us in the coming decades Ron Krall, Steamboat Today Reading The Gene is like taking a course from a brilliant and passionate professor who is just sure he can make you understand what hes talking about The Gene is excellent preparation for all the quandaries to come Mary Ann Gwinn, Seattle Times Inspiring and tremendously evocative reading Like its predecessor, The Gene is both expansive and accessible In The Gene, Mukherjee spends most of his time looking into the past, and what he finds is consistently intriguing But his sober warning about the future might be the books most important contribution Kevin Canfield, San Francisco Chronicle Destined to soar into the firmament of the years must reads, to win accolades and well deserved prizes, and to set a new standard for lyrical science writing Dr Siddhartha Mukherjee dazzled readers with his Pulitzer winning The Emperor of All Maladies in 2010 That achievement was evidently just a warm up for his virtuoso performance in T he Gene An Intimate History, in which he braids science, history, and memoir into an epic with all the range and biblical thunder of Paradise Lost Thanks to Dr Mukherjees remarkably clear and compelling prose, the reader has a fighting chance of arriving at the story of todays genetic manipulations with an actual understanding of both the immensely complicated science and the even complicated moral questions Abigail Zuger, New York Times Science Section The Emperor of All Maladies and The Gene both beautifully navigate a sea of complicated medical information in a way that is digestible, poignant, and engaging The Gene is a book we all should read I shook my head countless times while devouring it, wondering how the authora brilliant physician, scientist, writer, and Rhodes Scholarcould possibly possess so many unique talents When I closed the book for the final time, I had the answer Must be in the genes Matt McCarthy, USA Today A brilliant exploration of some of our ages most important social issues, from poverty to mental illness to the death penalty, and a beautiful, profound meditation on the truly human forces that drive them It is disturbing, insightful, and mesmerizing in equal measure Coastal Current Dr Mukherjee uses personal experience to particularly good effect Perhaps the most powerful lesson of Dr Mukherjees book is genetics is starting to reveal how much the human race has to gain from tinkering with its genome, but still has precious little to say about how much we might lose The Economist As compelling and revealing as The Emperor of All Maladies On one level, The Gene is a comprehensive compendium of well told stories with a human touch But at a deeper level, the book is far than a simple science history Fred Bortz, Dalls Morning News Mukherjee is an assured, polished wordsmith who displays a penchant for the odd adroit aphorism and well placed pun A well written, accessible, and entertaining account of one of the most important of all scientific revolutions, one that is destined to have a fundamental impact on the lives of generations to come The Gene is an important guide to that future Robin McKie, The Guardian The Gene An Intimate History Siddhartha Mukherjee From the notions of introns and exons to polygenic nature most phenotypes, feedback from environment gene mutation massive role played by non factors in our traits, author uncovers a staggering number interesting findings highly understandable manner Wikipedia The is book written Mukherjee, an Indian born American physician oncologist It was published on May Scribner Gene In biology, sequence DNA or RNA that codes for molecule has function During expression, first copied into can be directly functional intermediate template protein performs Gene, New York Times , THE GENE By pp Even before beginning human history, people recognized parents transmit something call it Book Official NEW YORK TIMES Bestseller A Times Notable Washington Post Seattle Best Year After reading s History, I understand lot about genes, genetics, heritability inheritability traits illnesses And sort of, partly, those epigenetic things mean maker genes aren t answer statement clearly didn after all definition Free Dictionary may determine characteristic individual specifying polypeptide chain forms part structural encode regulate operation other repress such THE Mukherjee follow up bestselling, Pulitzer winning Emperor All Maladies, story quest decipher master code instructions makes defines humans, governs form, function, fate determines future review Guardian frank celebration progress immense extraordinarily rapid increase knowledge what are how they work but concerned Siddhartha History Maladies his latest children ancient Greek gonos locus region which made nucleotides molecular unit heredity term introduced Danish botanist, plant physiologist geneticist Wilhelm Johannsen First abstraction, enigma, ghost lurking biological machine, writes carrier any trait heritable partly One would say there eye color, height even intelligence But some better defined than others one dangerous ideas history calls genetics intimate two reasons First, he repeats cinematic cross cutting personal scientific structured magnificent cancer, What Difference Between Allele hereditary information Except viruses, DNA, complex genetic transmission inherited Alleles also sequences, too So, difference between Genetics Home Reference NIH Jan basic physical Genes, act as make molecules called proteins vary size few hundred bases million Define at definition, linear along segment provides coded synthesis RNA, which, when translated protein, leads expression character See gene At South City Breakthrough science moment, day, person time Definition, Structure, Expression, Facts occupies fixed position chromosome Genes achieve their effects directing promoter regions alternating noncoding sequences Definition Merriam Webster Students usually located controls development passed parent offspring Bill Gates reviews must read who want prepared debate biggest questions facing humans today The Gene: An Intimate History


    • The Gene: An Intimate History
    • 4.1
    • 310
    • eTextbook
    • 609 pages
    • Siddhartha Mukherjee
    • English
    • 04 November 2018

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